Volume 2 ; Issue 2 ; in Month : Apr-June (2018) Article No : 127
Zaheer S, Nasar H, Sundus, et al.

Abstract

Recent advancement made in oral treatment of Hepatitis C shows a great improvement in number and types of drugs provided to physicians and pharmacists to decide for an intelligent treatment plan. This pharmacotherapy leads to more effective, better tolerable and shorten duration regimens. The new drugs approved by FDA are more reliable and safe than the previous ones, but as they are more selective for one or two genotypes, so this still provides a room for improvement and development in treatment options, for which continuous research is going on. Current review focuses on why the new drugs were introduced and how they were better than the preceding ones. The drugs discussed here are in chronological order of their discovery from 2014 to 2016, besides their comparison with each other. The studies of different researchers have contributed in the acknowledgement of mechanism of action, pharmacokinetics, pharmacodynamics, clinical behaviour and adverse events of these drugs. The importance of IV Interferons therapy switched to all-oral treatment. And the provision of guidelines for better treatment protocols.

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