Volume 9 ; Issue 2 ; in Month : July-Dec (2025) Article No : 193
Fazal B, Karim MJ, Kumar M, et al.

Abstract

Neurodegenerative disorders are largely defined by neuron loss. Growing older makes people more susceptible to neurodegenerative disorders (NDDs). Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and other neurodegenerative illnesses are typified by a progressive loss of neuronal structure and function that leads to the death of neuronal cells. Neurodegenerative disorders currently have no known cure, and the treatments that are available have poor efficacy and side effects. Neurodegenerative illnesses, despite their varied clinical presentations, are complex conditions with common characteristics and mechanisms include aberrant protein aggregation, mitochondrial dysfunction, oxidative stress, and Neuroinflammation. Targeting multiple mechanisms of action and utilising a neuroprotective approach, which aims to restore function to damaged neurons and prevent cell death, could be promising strategies for the prevention and treatment of neurodegenerative diseases, as multiple pathological mechanisms are linked to neurodegeneration. Herbal plants defines many plants with therapeutic benefits for treating neurodegenerative disorders that have antioxidant activity and describes the majority of neurodegenerative diseases. This review article provides knowledge regarding bioactive natural compounds with documented potential against neurodegeneratiion.

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