Volume 1 ; Issue 1 ; in Month : Jan-Mar (2017) Article No : 102
Akiladevi D, Nappinnai M, Jerad Suresh A, Amudha P

Abstract

Objective: The objective of the present study was to formulate and develop a self-emulsifying drug delivery system for poorly water soluble cardiovascular drug of atorvastatin calcium (atc) (SEDDS) by improving its solubility and dissolution characteristics, thereby enhancing its relative bioavailability. Methods: Atorvastatin calcium was identified by Fourier transform infrared (FT-IR) spectroscopic study. The SEDDS was prepared using sunflower oil, labrasol and transcutol HP as an oil phase, surfactant, and co-surfactant respectively. Initially, the solubility of atc was examined in different oils, surfactants and co-surfactants, and ternary phase diagrams were constructed subsequently to optimize the ratio of the excipients having greater microemulsion region. The self-emulsifying batches of atc were developed with the optimized excipients and evaluated for droplet size, polydispersity index, drug loading, zeta potential, optical clarity, turbidity, cloud point, viscosity determination, self-emulsification time assessment and in vitro drug release. Results: The in vitro dissolution studies revealed that the optimized formulation of atorvastatin calcium showed more than 90% of drug release within 30 minutes when compared to that of marketed tablet.

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