Evaluation of the Anti-inflammatory Activity and Ulcerogenic Risk of Sarenta, an Ivorian Herbal Preparation
Volume 2 ; Issue 3 ; in Month : July-Dec (2018) Article No : 131
Effo KE, Djadji ATL, Kouakou SL et al.
Sarenta is an Ivorian herbal preparation used for various purposes such its anti-inflammatory activity. On account of the ulcerogenic side effects of conventional anti-inflammatory drugs and in order to promote African traditional medicine, this study aimed to assess the anti-inflammatory activity and ulcerogenic risk of Sarenta.
The anti-inflammatory activity was evaluated by measuring the decrease in carrageenan- induced paw oedema in rat in acute model by Sarenta, then in sub-acute model by the decrease of the formation of granuloma induced by cotton pellets implanted subcutaneously in rats. Ulcerogenic risk was assessed by administering Sarenta alone to rats that were anesthetized 4 hours later. The ulcerogenic risk on gastric mucosa was evaluated and codified using a magnifying glass.
Sarenta at 10 mg/kg and 50 mg/kg induced a decrease in carrageenan-induced paw oedema in rat with an activity on the acute inflammation above 60% for the first 3 hours, above 70% at the 4th hour and beyond 80% at the 5th hour. Sarenta at the same doses did not affect rats gastric mucosa, showing a mucous membrane without erosions or petechiae. However, in a sub-acute inflammation model, Sarenta did not exhibit an anti-inflammatory activity 100 mg/kg and 200 mg/kg, a non-significant decrease in granuloma formation was recorded at a dose of 200 mg/kg.
In an acute inflammation model, Sarenta showed an anti-inflammatory activity with no ulcerogenic risk in animal. This herbal preparation represents an alternative for conventional non-steroidal anti-inflammatory drugs, as far as their ulcerogenic risks. However, in a sub-acute inflammation model, it did not show anti-inflammatory activity. Further investigations should be carried out that could lead to its introduction into anti-inflammatory therapeutic arsenal.
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