Volume 10 ; Issue 2 ; in Month : July-Dec (2026) Article No : 211
Akpabio EI, Effiong DE, Uwah TO, et al.

Abstract

Irvingia gabonensis (IG) gum is a biopolymer from Dika nuts. Its aqueous dispersion forms a viscous hydrocolloid with random coil conformations and has been used as matrix for controlled drug delivery. This work investigates its use to deliver ciprofloxacin as floating tablets. Dika nut was defatted and the IG gum chemically precipitated from aqueous dispersion was evaluated in the solid state and used in the formulation of ciprofloxacin floating tablet by wet granulation. Tablets were evaluated for buoyancy, mechanical and release properties. Tablet parameters were compared with those of other polymeric matrix-formers; guar gum, ethyl cellulose and hydroxypropyl-methyl-cellulose (HPMC). The obtained data were presented as descriptive statistics and compared using selected release kinetics and swelling kinetic models. Findings showed that IG gum had a yield of 15.2 % w/w, pH of 4.3, and a viscosity of 200 mPas. Matrix tablets of IG gum (F1) had floating lag time (FLT) of 4.5 seconds but total floating time was 24 hours. F4 (tablets with guar gum) however had an FLT of about 3 minutes. F1 followed a zero order release kinetics with a t90 of 7.8 hours, F3 and F4 (tablets with ethylcellulose and guar gum respectively) were best described by the Higuchi kinetic model. Only F2 (tablets with HPMC) had drug content left at the 12th hour of dissolution studies releasing only about 80% drug. Irvingia gum showed good potential for floating tablet matrix. With formulation optimization, the IG biopolymer will find usefulness in modified drug delivery.

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