Volume 10 ; Issue 2 ; in Month : July-Dec (2026) Article No : 206
Anand A, Mishra R, Pandey A, et al.

Abstract

Background: Gastric ulcer is a disorder that occurs when the stomach's lining becomes damaged. This deterioration transpires when the gastric lining lacks sufficient strength to safeguard itself from external factors. The gastric lining deteriorates. This facilitates the potential for adverse elements to inflict damage. Serotonin is a substance that can exacerbate damage to the stomach lining. It achieves this by inducing stress and inflammation in the gastric region. We aimed to investigate whether a substance known as Rutin may safeguard the stomach against ulcer formation. We conducted an experiment on rats to see whether Rutin can prevent the exacerbation of ulcers. We administered a substance to the rats that would induce ulcers. Subsequently, we administered Rutin to observe the outcome. We believe that Rutin may assist due to its characteristics that might alleviate inflammation and stress. We seek to determine whether Rutin can effectively inhibit the advancement of ulcers. We are endeavoring to avert the occurrence of stomach ulcers through the application of Rutin. This research could yield significant new insights on the therapeutic application of Rutin in the management and prevention of gastric ulcers linked to serotonin creatinine sulphate. Methodology: In experimental rats, the introduction of serotonin creatinine sulphate led to the formation of stomach mucosal ulcers. The rats were administered Rutin prior to that. The intensity of the ulcers was evaluated using the ulcer index. This indicates the degree of mucosal damage. Furthermore, we evaluated stress by the detection of reduced glutathione, catalase, superoxide dismutase and malondialdehyde. We investigated the tissues of the stomach for alterations. We ran analysis to identify the importance of the findings. P-value < 0.05 was determined to be statistically significant. The inquiry was focused on the evolution of stomach ulcers and putative protective impact of Rutin was given. Results: The injection of serotonin creatinine sulphate has an effect on the stomach. It made the activities of superoxide dismutase, catalase and glutathione go down a lot. This signifies that the stomach lining became destroyed because of excessive oxygen. The levels of malondialdehyde and ulcer index also went increased a lot. When we provided Rutin before that it helped a lot. The ulcer index fell lowered. There was less harm to the fats in the body. This suggests that Rutin can help prevent gastric troubles. Rutin also helped with inflammation. Increased the activity of natural antioxidant enzymes. When we looked at the stomach tissue we saw that the groups that had Rutin had a typical stomach anatomy. There were cells penetrating the stomach lining and the mucosal integrity was retained. This shows that Rutin can help prevent tissue damage and maintain the stomach structure stable. The serotonin creatinine sulphate caused a lot of damage. Rutin was able to counteract that. Rutin is particularly helpful, at supporting the stomach and keeping it healthy. Conclusion: Rutin's powerful gastro protective function has been proven by its clear protective impact against serotonin creatinine sulphate -induced stomach ulcers. Its cytoprotective and anti-inflammatory characteristics imply probable therapeutic use for the treatment of stomach ulcers. Given its capacity to decrease mucosal damage and retain stomach integrity, our results underline the need for greater research into Rutin as a potential treatment for ulcers.

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