Volume 10 ; Issue 1 ; in Month : Jan-June (2026) Article No : 202
Oladimeji OH, Alozie MF

Abstract

Background of study: Schiff bases are organic compounds noted for their versatility and exhibition of diverse biological activities including antioxidant, antibacterial, antifungal and antiviral amongst others. Hence, their significance in medicinal chemistry. Objectives: The worrisome resistance of microbes to anti-infective drugs in clinical therapy prompted the search for pharmaceutically active compounds with proven activities for treating disease conditions. Schiff base synthesis involving benzaldehyde and two alkyl amines was considered. Methodology: Benzaldehyde was separately reacted with hexyl amine and heptyl amine leading to imines. The antioxidant activity of the compounds was evaluated using the DPPH test. A comparison of the antioxidant activities so obtained was done to determine if the synthesized imines would show better activities than benzaldehyde and Vitamin C. The agar diffusion method was used for screening the compounds against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger for both antibacterial and antifungal potentials respectively. Results: Physico-chemical determinations and IR spectral technique have revealed the nomenclatures of both imines to be N-hexyl-1-phenyl methanimine and N-heptyl-1-phenyl methanimine respectively. The two imines did not give any antioxidant activity. However, the antibacterial and antifungal activities elicited by the imines showed concentration-dependency with Schiff base 2 being more antimicrobial than Schiff base 1. Conclusion: The results obtained especially from the antimicrobial tests show the two aldimines could be promising lead templates in the search for more efficacious biological agents especially in synergistic antimicrobial co-administration and formulation studies in drug development.

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