Volume 10 ; Issue 1 ; in Month : Jan-June (2026) Article No : 199
Shevante TB, Hande RA, Gaikwad DD, et al.

Abstract

Background: In order to treat type 2 diabetes mellitus, the study focuses on polyherbal anti-diabetic extracts from several plants that are administered at varying dosages. Ayurvedic medicines are widely accepted due to its efficacy, safety, affordability, ubiquity, and acceptance. Because polyherbal medicines comprise glycosides, alkaloids, flavonoids, and other compounds with different modes of action, they have been used for a long time to treat diabetes worldwide. This study examined the antidiabetic and haematological effects of polyherbal formulation (PHF) in diabetic rats induced with streptozotocin (STZ). Objective: To examine the antidiabetic effects of Polyherbal formulation on haematological parameters in streptozotocin-induced diabetic rats. Method: In this study,Wistar albino rats (n=6) were split up into five groups Streptozotocin was injected intraperitoneally to male Wistar rats to cause diabetes. After being confirmed diabetic, animals were treated orally with distilled water or extracts at 200 or 400 mg/kg body weight daily for 30 days. Results: Blood glucose levels were significantly decreased by the extract, with the highest results being at 400 mg/kg body weight. After extract administration at both doses, the quantities of red blood cells, white blood cells, and their functional keys all considerably increased. Also in diabetic rats, water and feed consumption were intensely decreased, and weight loss was minimized at both dosages.

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