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<title>Journal-of-Pharmaceutical-Research-Science-Technology-ISSUE VOLUME Volume 9 ISSUE Issue 2</title>
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Journal-of-Pharmaceutical-Research-Science-Technology: VOLUME Volume 9 ISSUE Issue 2, July-Dec 2025
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<managingEditor>editor@edwiserinternational.com</managingEditor>
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<title>Journal-of-Pharmaceutical-Research-Science-Technology-ISSUE VOLUME Volume 9 ISSUE Issue 2</title>
<link>http://ijpp.edwiserinternational.com/rss-feed.php</link>
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		<title>Hydrogel-based-oral-delivery-of-biologics-breaking-the-barrier</title>
		<pubDate>08-Sep-2025</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/YEQU7z.pdf</link>
		<author>Sharma-P-Kumar-R-Gulati-P</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Oral delivery of biologics offers unmatched advantages in patient compliance and therapeutic convenience but faces formidable challenges due to enzymatic degradation, poor epithelial permeability, and first-pass metabolism. Hydrogel-based delivery systems have emerged as a promising solution, leveraging their biocompatibility, tunable structures, and responsiveness to gastrointestinal stimuli to protect fragile biologic drugs and enhance their systemic bioavailability. This review explores the physiological barriers hindering oral biologic delivery and discusses advanced hydrogel design strategies, including mucoadhesion, pH-sensitive release, enzyme-responsive behavior, and nanoparticle embedding. Recent innovations such as microbiome-responsive hydrogels and artificial intelligence-assisted formulation design are reshaping the landscape, enabling smart, targeted, and patient-specific therapies. In vivo studies demonstrate significant improvements in pharmacokinetics, absorption, and therapeutic efficacy, while early clinical trials suggest a promising translational potential. However, regulatory, stability, and large-scale manufacturing challenges persist, necessitating further multidisciplinary collaboration. By overcoming these barriers, hydrogel-based oral delivery platforms are poised to revolutionize the administration of proteins, peptides, nucleic acids, and antibodies, offering a future where non-invasive, precision-targeted biologic therapies become the standard of care.]]>}</description>
		</item><item>
		<title>Pharmacological-aquatic-natural-product-Screening-for-bioactive-substances</title>
		<pubDate>08-Sep-2025</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/9dVUGn.pdf</link>
		<author>Fazal-B-Karim-MJ-Ranjan-S-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[In recent years, there has been a significant increase in the exploration and development of drugs derived from marine-based natural compounds. A wide array of marine organismsincluding fungi, halophytes, bacteria, cyanobacteria, and cone snailshave yielded promising chemical entities for pharmaceutical research. These biologically active compounds from natural marine sources are gaining considerable attention, especially those with potential to target key molecules involved in various diseases. Current studies are primarily focused on microorganisms such as bacteria and fungi isolated from marine sediments, algae, seaweeds, and invertebrates like sponges, mollusks, tunicates, and crabs. The marine environment presents promising opportunities for developing new therapies against bacterial, viral, fungal, and parasitic infectionsparticularly in light of growing resistance to conventional drugs and emerging infectious threats. Concerns such as bioterrorism, antimicrobial resistance, and newly arising infectious diseases have further fueled interest in marine-derived compounds, despite most clinical trials focusing primarily on cancer therapies. Marine natural products are generally categorized into three main biological sources: marine microorganisms (e.g., phytoplankton), marine algae, and marine invertebrates. Among these, the marine ecosystem is considered a highly productive reservoir of bioactive secondary metabolites. Compounds extracted from various types of algaeespecially brown algaeare of particular interest due to their wide-ranging biological functions and compatibility with human systems. The vast biodiversity within the oceans remains a largely untapped resource, offering numerous plant, animal, and microbial species with the potential to produce novel bioactive agents.]]>}</description>
		</item><item>
		<title>Bioactive-natural-compounds-potential-against-neurodegeneration</title>
		<pubDate>08-Sep-2025</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/O0krx5.pdf</link>
		<author>Fazal-B-Karim-MJ-Kumar-M-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Neurodegenerative disorders are largely defined by neuron loss. Growing older makes people more susceptible to neurodegenerative disorders (NDDs). Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and other neurodegenerative illnesses are typified by a progressive loss of neuronal structure and function that leads to the death of neuronal cells. Neurodegenerative disorders currently have no known cure, and the treatments that are available have poor efficacy and side effects. Neurodegenerative illnesses, despite their varied clinical presentations, are complex conditions with common characteristics and mechanisms include aberrant protein aggregation, mitochondrial dysfunction, oxidative stress, and Neuroinflammation. Targeting multiple mechanisms of action and utilising a neuroprotective approach, which aims to restore function to damaged neurons and prevent cell death, could be promising strategies for the prevention and treatment of neurodegenerative diseases, as multiple pathological mechanisms are linked to neurodegeneration. Herbal plants defines many plants with therapeutic benefits for treating neurodegenerative disorders that have antioxidant activity and describes the majority of neurodegenerative diseases. This review article provides knowledge regarding bioactive natural compounds with documented potential against neurodegeneratiion.]]>}</description>
		</item><item>
		<title>Next-generation-tuberculosis-therapy-from-drug-design-to-delivery</title>
		<pubDate>08-Sep-2025</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/cQ1JjM.pdf</link>
		<author>Yadav-DK-Mishra-R-Saini-P-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Background: Tuberculosis (TB) caused by Mycobacterium tuberculosis, continue to remain as one of the paramount infectious diseases especially in developing countries. Issues such as long duration of treatment, side effects to the drugs, and increasing resistance to drugs call for pharmaceutical and pharmacological measures to achieve better therapeutic results. Objective: This review will encompass recent therapeutic and pharmaceutical advances in the treatment of Tuberculosis and their potential applications to help overcome some limitations faced by current approaches of therapy. Methodology: The purpose of this review was to analyze relevant articles published over 2015 to 2025 with the assistance of the databases PubMed, ScienceDirect and Google Scholar. Selected articles are all peer reviewed and discuss novel drug delivery systems, pharmacokinetics of anti-TB agents, drug resistance mechanisms, and clinical efficacy of novel pharmacological agents. Both monotherapy and combination therapy, as well as adjunct formulations were analyzed. Result: New drug delivery technologies have enhanced the bioavailability and patient compliance. These include nanoformulations, liposomal carriers, inhalable drugs for TB and fixed-dose combinations. Appreciable results have been obtained against MDR and XDR TB strains with the advent of bedaquiline, pretomanid and delamanid. Together, these approaches forge a stronger and efficient treatment strategy against TB. Conclusion: TB control requires a 2 pronged drug pharmacological approach. Advances in drug delivery and pharmacotherapy hold the key to addressing the present treatment challenges and improving patient outcomes.]]>}</description>
		</item><item>
		<title>Epidemiology-and-management-of-cardiovascular-diseases-in-Kashmir-India-prevalence-risk-factors-and-strategies-for-improved-outcomes</title>
		<pubDate>15-Sep-2025</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/30AkVz.pdf</link>
		<author>Qadri-SMF-Khan-MF-John-S-et-al</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Cardiovascular diseases (CVD) represent a considerable public health challenge in India, particularly in regions such as Kashmir, where unique socio-environmental factors result in a scarcity of localized data. This study examines the prevalence, risk factors, and management strategies for cardiovascular disease (CVD) in Kashmir, India, utilizing a cross-sectional survey of 400 patient respondents.  Data was gathered on demographic characteristics, health and lifestyle factors, environmental and socio-cultural influences, CVD management practices, awareness, and readiness for emergencies. Initial results show that CVDS are very common. Some of the main risk factors are smoking, not getting enough exercise, being under a lot of stress, and having a family history of CVD or related conditions. Cold weather and limited access to health care in rural areas were all important factors. Management Problems include costs, long distances to healthcare facilities, and lack of knowledge about how to prevent problems. The study suggests specific actions to improve CVD outcomes, such as health education in the community, subsidized screenings, better emergency response systems (like ambulances and telemedicine), and lifestyle programs that are tailored to different cultures. These results highlight the need for region-specific public health strategies to mitigate the escalating CVD burden in Kashmir.]]>}</description>
		</item><item>
		<title>A-Text-Mining-Study-on-Sustainable-Health-Solution-for-Indias-Most-Vulnerable-Population</title>
		<pubDate>13-Nov-2025</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/9THzmv.pdf</link>
		<author>Dhamija-S-Jamshed-M-Ahmad-A-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Health disparity between urban and rural India has existed since very long back in history. Text mining techniques in the given context are used to compile 140 peer-reviewed journal articles published in the WoS database focusing more on the core theme, disparities, as well as the policy aspects related to the delivery of health services in both the urban and rural sectors.The results explain the disparities in the health infrastructure available to the country as a whole, adherence to digital health technology, as well as the financial status. Urban areas possess improved health services as well as advanced digital platforms compared to rural areas, where basic services as well as digital technologies are currently lagging. The factors identified as the bridge between the gaps in rural health services are the greater acceptance of telemedicine, mobile health (mHealth), and AI-based interventions. Community programs initiated under Accredited Social Health Activists (ASHA)s and non-governmental organizations (NGOs) worked towards adding positively to improved accessibility. Government programs like Ayushman Bharat and National Rural Health Mission (NRHM) improved health insurance coverage. However, fears about the functionality remain. This study emphasizes the importance of informed decision-making, effective financing strategies for the protection of health, or rather the development of appropriate community-based responses to health care. This particular publication contributes towards the body of knowledge in the area of inequality in health care delivery in India. ]]>}</description>
		</item><item>
		<title>Smart-Delivery-of-a-Novel-Sulfur-Containing-Heterocycle-through-a-ChitosanStearic-Acid-based-PolymerDrug-Conjugate-A-Redox-Sensitive-Strategy-for-Enhanced-Anticancer-Activity</title>
		<pubDate>13-Nov-2025</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/X1BSjP.pdf</link>
		<author>Noushin-Golzar</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Sulfur-containing heterocycles (SHCs) have emerged as an important class of bioactive compounds with promising applications in cancer therapy, owing to their structural diversity, redox activity, and ability to interfere with multiple oncogenic pathways. However, their therapeutic potential is often limited by poor aqueous solubility, instability in circulation, and reduced efficacy against multidrug-resistant (MDR) tumors. In this study, we aimed to evaluate the anticancer activity of a novel SHC previously developed by our team and to enhance its performance through a redox-responsive nanodelivery system. Chitosanstearic acid (CSSA) was synthesized via EDC-mediated amidation and subsequently conjugated to SHC through a disulfide linker, yielding SHCssCSSA micelles. Structural verification by ^1H NMR confirmed successful conjugation, and UVvisible spectrophotometry determined the SHC content to be 11.3% (w/w). The amphiphilic conjugates self-assembled into stable micelles with a mean diameter of 56 nm, low polydispersity, and positive zeta potential, exhibiting a reduced critical micelle concentration compared to CSSA alone. Redox-responsiveness was confirmed by dithiothreitol-triggered release, where SHCssCSSA micelles displayed rapid cleavage of disulfide bonds and efficient drug liberation under intracellular-like reductive conditions, but remained stable in extracellular-like environments. Cytotoxicity assays in T47D breast cancer cells and their resistant counterpart T47D/SN150 demonstrated that SHCssCSSA micelles significantly enhanced anticancer potency compared to free SHC, reducing IC values and achieving a resistance reversal index of 3.62. The improved efficacy may be attributed to endocytic uptake, bypass of MRP/BCRP efflux, redox-triggered intracellular release, and potential nuclear enrichment facilitated by chitosans GlcNAc structure. Collectively, these findings show that SHCssCSSA micelles not only potentiate the anticancer activity of a novel sulfur-containing heterocyclic compound but also effectively overcome transporter-mediated MDR, offering a promising and safe platform for targeted cancer therapy. ]]>}</description>
		</item><item>
		<title>Essential-Drugs-Accessibility-and-its-Impact-on-Elderly-Population-A-Mixed-Method-Study-in-Bihar</title>
		<pubDate>08-May-2026</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/CvExGM.pdf</link>
		<author>Hussain-MA-Ravichandran-N-Khan-J-et-al</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[The availability of essential drugs is a very important factor for sustaining the health and well-being of the population, particularly the elderly, who are often burdened with chronic and age-related illnesses. In Bihar, one of India's most populous and resource-constrained states, the health supply chain faces significant challenges that lead to frequent unavailability of essential drugs. This paper examines the impact of supply chain inefficiencies on the elderly population, highlighting underlying factors such as unavailability/stockouts of essential drugs related to the elderly population in Bihar. By analyzing data and case studies, this study proposes actionable solutions to improve the healthcare supply chain commodities, ensuring equitable availability of essential medicines for the elderly residents of Bihar.]]>}</description>
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