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<title>Journal-of-Pharmaceutical-Research-Science-Technology-ISSUE VOLUME Volume 8 ISSUE Issue 1</title>
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Journal-of-Pharmaceutical-Research-Science-Technology: VOLUME Volume 8 ISSUE Issue 1, Jan-June 2024
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<title>Journal-of-Pharmaceutical-Research-Science-Technology-ISSUE VOLUME Volume 8 ISSUE Issue 1</title>
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		<title>Exploring-ethnomedicinal-plants-for-treating-diverse-skin-ailments-among-tribal-communities-in-Mizoram-India-insights-from-traditional-healing-practices</title>
		<pubDate>14-May-2025</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/DxbSHj.pdf</link>
		<author>Kumar-S-Kushari-S-Gam-S-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[hroughout history, plants have been extensively utilized in traditional medicine for primary healthcare purposes. It is recognized that medicinal plants contain a diverse array of bioactive compounds, making them an alternative option to synthetic medications for addressing a variety of illnesses. The primary aim of this review is to compile comprehensive data on folk medicinal plants utilized by diverse tribal communities in Mizoram, India, as traditional remedies for treating various skin diseases. A thorough literature review was conducted utilizing various sources including books and electronic databases to gain insights into the etiology of skin diseases and the corresponding traditional herbal treatments. Results: Ninety-five plant species from fifty different families have been identified for their ethnomedicinal properties in treating various skin conditions. Roots, rhizomes, stems, leaves, barks, bulbs, flowers, and even whole plants are employed as folk remedies to address a range of skin infections, often administered in the form of crushed juice, paste, or decoction.Conclusion: This information serves to guide researchers in identifying previously unexplored medicinal plants, offering avenues for developing novel therapeutic approaches and isolating and identifying new bioactive compounds that are both safe and cost-effective.]]>}</description>
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		<title>Novel-aryl-substituted-alkenol-ladimejol-from-the-chemical-modifications-of-caffeic-acid-and-prospection-for-its-potential-biological-activities</title>
		<pubDate>14-May-2025</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/RyzksN.pdf</link>
		<author>Oladimeji-OH-Nkwachukwu-CM-Opara-CM-et-al-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Background: Caffeic acid is a poly-phenolic compound which can be obtained from natural sources such as coffee, turmeric, oregano, mushrooms, vegetables and fruits amongst many others. This acid and a number of its synthesized derivatives have shown different activities such as anti-diabetic, antiviral, anti-inflammatory, anti-aging, cardio-protective potentialities, antioxidant and antimicrobial amongst others. This necessitated the present study. Objectives: Increasing concerns about the debilitating effects of free radical species have become a source of worry to man hence the attention of the scientific world. These chemical species routinely wrought damages in human cells, tissues and organs resulting in a host of diverse patho-physiological and neurodegenerative conditions. Furthermore, the growing resistance to antibiotics and antifungal drugs has encouraged the search for lead compound(s) with the aim of chemically modifying the molecular structure(s) of compounds/drugs/chemicals or synthesizing derivatives from different reactions involving them. The search for novel and pharmacologically active derivatives with the aim of reducing the effects or out-right termination of these conditions led to the choice of caffeic acid.Methodology: The pro-drug, caffeic acid was subjected to different synthetic procedures such as esterification, acetylation and reduction. The melting points, refractive indices and optical rotations of the acid and derivatives were obtained. The antioxidant activity (IC50) of caffeic acid and synthesized products was determined using the DPPH (2, 2-diphenyl-1-picrylhydrazyl hydrate) test. A comparison of the obtained antioxidant activities was done to determine if any improvements could be noticed in the derivatives. The agar-in-hole method was adopted for screening caffeic acid and the synthesized compounds against Staphylococcus aureus, Escherichia coli and Candida albicans for antibacterial and antifungal activities respectively.Results: The identities of the derivatives have been revealed to be ethyl caffeate (CE), acetyl caffeate (CA) and 1-(3,4-dihydroxy phenyl)-2-propen-3-ol (3,4-benzenediol-2-propen-3-ol) (CR), a novel aryl substituted alkenol assigned the trivial nomenclature of (Ladimejol) respectively using a combination of physico-chemical determinations and IR spectral technique. Caffeic acid, (CE), and (CA) demonstrated significant antioxidant activity (IC50)  of 0.22, 0.19 and 0.16 g/mL respectively which compare favourably with 0.18 g/mL obtained with Vitamin C (a standard antioxidant drug). The acetyl derivative gave a comparably remarkable antioxidant activity than Vitamin C. However, the antioxidant activity of (CR) (Ladimejol) could not be regressed in this study. The antibacterial and antifungal activities elicited by both caffeic acid and obtained derivatives were concentration-dependent. Furthermore, the acetyl derivative (CA) was distinctly more bacteriostatic than the other two synthesized products against the test bacteria and was also hugely anti-candidal. In addition this derivative elicited higher activities than even caffeic acid. The reduced product (CR) (Ladimejol) recorded no growths in the screening for both antibacterial and antifungal activities.Conclusion: The results from this study indicate that the synthesized novel aryl substituted alkenol, 1-(3,4-dihydroxy phenyl)-2-propen-3-ol (3,4-benzenediol-2-propen-3-ol) (CR) (Ladimejol) did not show any potentialities for antioxidant, antibacterial and antifungal activities. However, the acetyl caffeate (CA) demonstrated significant antioxidant, antibacterial and antifungal activities. Hence, acetyl caffeate could be considered as a lead candidate compound in the search for newer and more efficacious antioxidant and antimicrobial agents in more expanded structural activity relationship studies (SARS), drug design development and formulation studies.]]>}</description>
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		<title>Harnessing-the-power-of-life-synthetic-biology-for-next-generation-chemical-synthesis</title>
		<pubDate>14-May-2025</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/Q8chMO.pdf</link>
		<author>Joshi-NM-Gharia-B-</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Synthetic biology is a new exciting field that has been defined as a new tool to address chemical synthesis problems and issues, which are beyond the capabilities of conventional approaches. This review paper, "Harnessing the Power of Life: Synthetic Biology for Next-Generation Chemical Synthesis is an excellent paper that offers a detailed analysis of the incorporation of synthetic biology into the synthesis process. Prelims of the paper include an introduction that discusses the application of chemical synthesis in different fields and the rationale for using synthetic biology, the subsequent sections that describe the principles, methods, and instruments of synthetic biology. It compares them with the traditional chemical synthesis methods where these issues and difficulties are embedded. The combined importance of synthetic biology and chemical synthesis is highlighted together with the benefits and opportunities arising from the synergy of both fields. Some of the approaches to design microorganisms to produce desirable chemicals involve metabolic engineering and pathway optimization are highlighted with examples that demonstrate how they lead to improved yield and productivity. The review also discusses biocatalysis, with the emphasis on enzyme engineering and directed evolution as the key strategies for the addition of the chemical synthesis toolkit. Design of synthetic routes for the synthesis of specific target molecules is discussed, with particular focus on rational design approaches and the use of computation tools. By explaining a number of real-life examples, the paper reveals how synthetic biology has been implemented practically across the realms of pharmaceutical and chemical manufacturing and specialty materials. It also highlights the current technical issues and limitations, as well as regulatory and ethical issues, in order to give some consideration of future developments and potential advances in the area. In conclusion, drawing the main ideas outlined in the paper, the review emphasizes major findings and their future impact on the further development of synthetic biology as a breakthrough in chemical synthesis evolution.]]>}</description>
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