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<title>Journal-of-Pharmaceutical-Research-Science-Technology-ISSUE VOLUME Volume 7 ISSUE Issue 1</title>
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Journal-of-Pharmaceutical-Research-Science-Technology: VOLUME Volume 7 ISSUE Issue 1, Jan-June 2023
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<language>en-us</language>
<managingEditor>editor@edwiserinternational.com</managingEditor>
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<title>Journal-of-Pharmaceutical-Research-Science-Technology-ISSUE VOLUME Volume 7 ISSUE Issue 1</title>
<link>http://ijpp.edwiserinternational.com/rss-feed.php</link>
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		<title>Synthesis-of-Pyrazole-Derivative-Incorporating-Fluorine-in-the-Aromatic-Substitution-for-Physiological-and-Pharmacological-Studies</title>
		<pubDate>21-Jul-2023</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/M3x2gL.pdf</link>
		<author>Ravi-Gautam-and-Mukesh-Kumar-Gupta</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Over the past decade, drug resistance has become a growing problem in the treatment of infectious diseases caused by bacteria, fungi and viruses. In particular, resistance of bacterial pathogens to current antibiotics has emerged as a measure of health problems. This is especially true in the case of infectious diseases such as pneumonia, meningitis and tuberculosis, which would once have been easily treated with antibiotics, is no longer so readily treated. At present, all widely used antibiotic, including some of the agent such as streptogramins and new generation fluoroquinolones are subjected to bacterial resistance. The search for new antimicrobial agent is one of the most challenging tasks to the medicinal chemist. A search for new antimicrobial compounds with potent and minor toxicity continues to be a region of exploration in medicinal chemistry. It has been well recognized that nitrogen containing heterocyclic molecule is a seat of diverse medicinal activities. Heterocyclic nucleus Pyrazole constitutes an important class of compounds for new drug development. The synthesis of these derivatives and investigation of their chemical and biological behavior have gained more importance in recent decades. Owing to the pharmacological importance of Pyrazole, and its derivatives, in the present work, it has been contemplated to combine various biologically active moieties with these heterocycles through active functional systems to form new molecular framework. Prompted by the therapeutic importance of these heterocyclic derivatives, in the present research work we have synthesized Pyrazole with fluorinated aromatic rings, and its derivatives through multistep reaction. Appropriate synthetic methodologies have been developed for the synthesis of new molecules. Their purification techniques have been established. All the newly synthesized compounds have been characterized by 1H NMR, 13C NMR, mass spectral, IR and elemental analyses. Also structures of a few molecules have been confirmed by X-ray crystallographic analysis. Further, the target molecules have been evaluated for their in vitro antibacterial and antifungal activity. From the pharmacological evaluation, it has been observed that some of Pyrazole, derivatives showed good antimicrobial activity.]]>}</description>
		</item><item>
		<title>Licorice-Glycyrrhiza-glabra-L-A-Unique-Herbaceous-Plant-Review-of-its-Medicinal-Uses</title>
		<pubDate>21-Jul-2023</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/vwD49a.pdf</link>
		<author>Mohammad-Makhmur-Ahmad-Mohd-Rashid</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Since the beginning of human civilization numerous plants have been used extensively as an essential medicinal source. The need for natural medications is steadily growing over time. One of the herbal plants that is most frequently used in foods, medicines, and extensive global study is licorice or sweetwood as Glycyrrhiza glabra belongs to family Fabaceae. It was used in traditional and complementary medicine to treat a variety of ailments such as allergies, liver toxicity, gastric ulcer, lung diseases, skin disorders, oral health issues such as tooth decay, and inflammation. The phytochemical constituents of licorice include various essential oils, sugars, inorganic salts, resins, amino acids, and nucleic acids. Licorice active substances such as triterpene, flavonoids, and saponins have been shown to exhibit biological activity. Licorice has been extensively researched in recent years to find its benefits, constituents and mechanism of action.  This review summarizes the therapeutic and pharmacological benefits of licorice, as well as its applications in various health-related conditions along with its toxicity and maximum amounts of licorice consumption.]]>}</description>
		</item><item>
		<title>Walatimine-Vanillyl-Butyl-Imine-A-New-Ketimine-from-Schiff-Base-Synthesis-and-Evaluation-of-its-Antioxidant-Antibacterial-and-Antifungal-Properties</title>
		<pubDate>21-Jul-2023</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/N4hH7k.pdf</link>
		<author>Oladimeji-OH-Olukoju-JA-Ogbu-SO-et-al</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Background of study: Vanillin is a white crystalline compound which is a phenolic aldehyde with a balsamic flavour. It is widely obtained from vanilla bean-pods amongst very many other sources. This compound and some of its derivatives possess diverse activities including anticancer, anti-inflammatory, antioxidant, antibacterial and antifungal amongst others. Hence, the import of this study. Objectives: The growing concerns about the deleterious actions of free radical oxygenated species (FROS) in the human body have become a huge concern to the scientific world. These chemical species continually devastate the human cells, tissues and organs leading to different pathophysiological conditions and neurodegenerative disorders. Also, the noticeable microbial resistance to antibiotics and antifungal drugs have prompted the search for lead compound(s) with the aim of chemically modifying its/their molecular structure(s) or synthesizing other compounds from reactions involving them such as Schiff base synthesis. The search for novel pharmaceutically active compounds with the aim of ameliorating these conditions led to the choice of vanillin.  Methodology: Vanillin was subjected to the Schiff base synthesis. It was reacted separately with amines (aromatic and aliphatic amine) leading to the bases in the presence of acid. The melting points, refractive indices and optical rotations of the vanillin and the Schiff bases were obtained. The antioxidant activity (IC50) of the lead compound and bases was determined employing the DPPH (2, 2-diphenyl-1-picrylhydrazyl hydrate) bench-top assay test. Comparison of the obtained antioxidant activities was done to determine if any improvements could be noticed in the synthesized bases. Also, the agar-in-hole diffusion method was adopted for screening vanillin and the synthesized bases against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeriginosa and Candida albicans for antibacterial and antifungal activities respectively.Results: The identities of the synthesized Schiff bases have been revealed to be vanillyl butyl imine (W) a new ketimine referred to by the trivial name-Walatimine and vanillin-2,4-dinitrophenyl hydrazone (Vdnp) respectively using a combination of physico-chemical determinations and IR spectral technique. Vanillin and (W) demonstrated marginal antioxidant activity of IC50 of 0.52 and 0.50 g/mL respectively while Vdnp gave a remarkably significant IC50 of 0.48 and which compare favourably with 0.46 g/mL elicited by Vitamin C (a standard antioxidant drug). The antibacterial and antifungal activities elicited by both W and Vdnp were concentration dependent. Furthermore, Vdnp was comparably more bacteriostatic than W against the test bacteria though it was inactive against Ps. aeriginosa. However, vanillyl butyl imine (W) was slightly more anti-candidal against C. albicans than vanillin-2,4-dinitrophenyl hydrazone (Vdnp). Conclusion: The results from this study indicate that vanillin-2,4-dinitrophenyl hydrazone (Vdnp) obtained from the condensation reaction of vanillin and an aromatic amine affords a comparably better antioxidant activity than W obtained from vanillin reacting with an aliphatic amine. Both W and Vdnp demonstrated remarkable antibacterial and antifungal activities hence, these two synthesized Schiff bases can be lead candidate compounds in the search for newer and more efficacious antioxidant and antimicrobial agents and in further structural activity relationship studies (SARS) and as well as in formulation studies in drug development.]]>}</description>
		</item><item>
		<title>An-Observational-Study-of-Type-2-Diabetes-Mellitus-Patients-from-a-Small-Town-of-Bihar-India</title>
		<pubDate>21-Jul-2023</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/z4VPCN.pdf</link>
		<author>Verma-AK-Kumar-A-Hayat-M-et-al</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[This study was conducted to describe the profile of patients with type 2 diabetes mellitus from a small town of Bihar, India. This study was conducted over 98 patients of Type 2 Diabetes Mellitus, who were taking treatment from a specialized diabetic hospital of Bihar Sharif, headquarter of Nalanda district of Bihar state, India. The study was conducted during January 2023 to March 2023. The patients were requested to complete a questionnaire including their risk profile (hypertension, obesity, dyslipidaemia, and glycaemic status), sociodemographic factors, general health, symptoms present, family history of diabetes, physical activity, diet control, medications (oral hypoglycemic agents, insulin injections, antihypertensives, etc.) and habits present (tobacco chewing, alcohol consumption and smoking). Blood pressure (BP), body mass index (BMI), fasting blood sugar (FBS) level and lipid profile were also included in the questionnaire. Overall, 98 type 2 diabetes mellitus (T2DM) patients with mean age of 60.237.50 years were studied. Out of 98 patients, 43 (43.87%) were male and 55 (56.12%) were female. Most of the T2DM patients (42.86%) were obese, and 70.40% had a positive family history of diabetes. 11.22% of patients had vision impairment. The mean FBS level was 188.1171.10 mg/dl and good glycemic control (FBS level ]]>}</description>
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