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<title>Journal-of-Pharmaceutical-Research-Science-Technology-ISSUE VOLUME Volume 2 ISSUE Issue 3</title>
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Journal-of-Pharmaceutical-Research-Science-Technology: VOLUME Volume 2 ISSUE Issue 3, July-Dec 2018
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<title>Journal-of-Pharmaceutical-Research-Science-Technology-ISSUE VOLUME Volume 2 ISSUE Issue 3</title>
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		<title>Evaluation-of-the-Anti-inflammatory-Activity-and-Ulcerogenic-Risk-of-Sarenta-an-Ivorian-Herbal-Preparation</title>
		<pubDate>08-Jan-2019</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/bmgnfc.pdf</link>
		<author>Effo-KE-Djadji-ATL-Kouakou-SL-et-al</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Sarenta is an Ivorian herbal preparation used for various purposes such its anti-inflammatory activity. On account of the ulcerogenic side effects of conventional anti-inflammatory drugs and in order to promote African traditional medicine, this study aimed to assess the anti-inflammatory activity and ulcerogenic risk of Sarenta.The anti-inflammatory activity was evaluated by measuring the decrease in carrageenan- induced paw oedema in rat in acute model by Sarenta, then in sub-acute model by the decrease of the formation of granuloma induced by cotton pellets implanted subcutaneously in rats. Ulcerogenic risk was assessed by administering Sarenta alone to rats that were anesthetized 4 hours later. The ulcerogenic risk on gastric mucosa was evaluated and codified using a magnifying glass.   Sarenta at 10 mg/kg and 50 mg/kg induced a decrease in carrageenan-induced paw oedema in rat with an activity on the acute inflammation above 60% for the first 3 hours, above 70% at the 4th hour and beyond 80% at the 5th hour. Sarenta at the same doses did not affect rats gastric mucosa, showing a mucous membrane without erosions or petechiae. However, in a sub-acute inflammation model, Sarenta did not exhibit an anti-inflammatory activity 100 mg/kg and 200 mg/kg, a non-significant decrease in granuloma formation was recorded at a dose of 200 mg/kg. In an acute inflammation model, Sarenta showed an anti-inflammatory activity with no ulcerogenic risk in animal. This herbal preparation represents an alternative for conventional non-steroidal anti-inflammatory drugs, as far as their ulcerogenic risks. However, in a sub-acute inflammation model, it did not show anti-inflammatory activity. Further investigations should be carried out that could lead to its introduction into anti-inflammatory therapeutic arsenal.]]>}</description>
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		<title>Boswellic-Acids-Pretreatment-Enhances-the-Bioavailability-and-Hypoglycemic-Action-of-Metformin-in-Rats-Involvement-of-CYP3A-Inhibition</title>
		<pubDate>08-Jan-2019</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/qFCT9k.pdf</link>
		<author>Sujatha-Samala-and-Ciddi-Veeresham</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Herbal antidiabetic preparations are often used as an add-on therapy in diabetes. Hence in the present investigation the effect of boswellic acids (BA) on the bioavailability and hypoglycemic action of metformin in normal as well as diabetic rats was studied. In normal and streptozotocin induced diabetic rats the combination of metformin with BA increased all the pharmacokinetic parameters such as Cmax, AUC0-n, AUCtotal, t, MRT and decreased the clearance, Vd markedly as compared to control group. In intestinal and liver microsomes BA at 10M has shown CYP3A4 inhibitory activity significantly (p]]>}</description>
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		<title>Liposomal-Nanoformulation-of-Piperlongumine-for-Improved-Aqueous-Solubility-and-Enhanced-Anti-tumour-Activity-In-vitro</title>
		<pubDate>15-Jan-2019</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/vNIZ8F.pdf</link>
		<author>Alamri-A-Huang-Y-Zhang-H</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Piperlongumine (PL) is an alkaloid isolated from the Piper species, which can induce apoptosis in cancer cells but has little inhibitory effect on the growth of normal cells. However, its poor aqueous solubility has largely limited its therapeutic applications. To address this issue, we developed liposomal nanoformulations for PL (nanoPLs) in this study. The optimized nanoPLs exhibited a small average diameter in the range of 100-160 nm and narrow size distribution as well as high encapsulation efficiency. NanoPLs also demonstrated excellent storage stability at 4C for 12 weeks. The apparent solubility of PL in NanoPLs was improved up to 312 folds than in PBS. NanoPLs also markedly increased the cytotoxicity of PL to human prostate cancer PC-3 cells when compared to free PL. NanoPLs represent promising and convenient injectable formulations of PL for further preclinical and clinical investigation.]]>}</description>
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