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<title>Journal-of-Pharmaceutical-Research-Science-Technology-ISSUE VOLUME Volume 1 ISSUE Issue 1</title>
<link>http://ijpp.edwiserinternational.com/rss-feed.php</link>
<description>
Journal-of-Pharmaceutical-Research-Science-Technology: VOLUME Volume 1 ISSUE Issue 1, Jan-Mar 2017
</description>
<language>en-us</language>
<managingEditor>editor@edwiserinternational.com</managingEditor>
<webMaster>editor@edwiserinternational.com</webMaster>
<copyright>editor@edwiserinternational.com</copyright>
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<title>Journal-of-Pharmaceutical-Research-Science-Technology-ISSUE VOLUME Volume 1 ISSUE Issue 1</title>
<link>http://ijpp.edwiserinternational.com/rss-feed.php</link>
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		<title>Type-2-Diabetes-Current-and-Future-Medications-A-Short-Review</title>
		<pubDate>03-Jun-2018</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/LRE1Uy.pdf</link>
		<author>Jahangir-MA-Imam-SS-Kazmi-I-Muheem-A</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Diabetes Mellitus (DM) is a complex set of disease. It is basically a metabolic disorder in which body is unable to make enough insulin or it is not able to use insulin effectively or in some instances both. According to global report on diabetes released by World Health Organization, Geneva 422 million people suffers from diabetes in 2014. The number is expected to increase to 552 million by 2030.  A number of researches are going on around the globe by pharmaceutical companies to exploit the huge market it provides. This short review covers the brief basics of DM and its classification medication. This review mainly focus on type 2 diabetes discussing the new classification of medication available in the market as well as the approved antidiabetic drugs for type 2 diabetes by USFDA after 2010 and the pipeline antidiabetic drugs under clinical trials. This short review article has been prepared reviewing data available from PubMed, National Institute of Health, USFDA, clinicaltrials.gov and other related sites.]]>}</description>
		</item><item>
		<title>Self-emulsifying-Delivery-System-in-Solubility-and-Dissolution-Enhancement-of-Cardiovascular-Drug</title>
		<pubDate>03-Jun-2018</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/C8yVxv.pdf</link>
		<author>Akiladevi-D-Nappinnai-M-Jerad-Suresh-A-Amudha-P</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Objective: The objective of the present study was to formulate and develop a self-emulsifying drug delivery system for poorly water soluble cardiovascular drug of atorvastatin calcium (atc) (SEDDS) by improving its solubility and dissolution characteristics, thereby enhancing its relative bioavailability.Methods: Atorvastatin calcium was identified by Fourier transform infrared (FT-IR) spectroscopic study. The SEDDS was prepared using sunflower oil, labrasol and transcutol HP as an oil phase, surfactant, and co-surfactant respectively. Initially, the solubility of atc was examined in different oils, surfactants and co-surfactants, and ternary phase diagrams were constructed subsequently to optimize the ratio of the excipients having greater microemulsion region. The self-emulsifying batches of atc were developed with the optimized excipients and evaluated for droplet size, polydispersity index, drug loading, zeta potential, optical clarity, turbidity, cloud point, viscosity determination, self-emulsification time assessment and in vitro drug release. Results: The in vitro dissolution studies revealed that the optimized formulation of atorvastatin calcium showed more than 90% of drug release within 30 minutes when compared to that of marketed tablet.]]>}</description>
		</item><item>
		<title>Protective-Effect-of-Cleome-Viscosa-Extract-on-Diet-Induced-Atherosclerosis-in-Diabetic-Rats</title>
		<pubDate>03-Jun-2018</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/NkR9yg.pdf</link>
		<author>Faheemuddin-M-Janardhan-M-Hassan-M</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[The atherosclerotic effect of Methanolic extract of Cleome viscosa was studied in Streptozotocin induced Diabetic Rats fed with Atherogenic Diet [1.5 ml olive oil containing 8 mg of vitamin D-2 and 40 mg cholesterol] for 5 consecutive days. Oral administration of extract to diabetic rats [250 mg/kg and 500 mg/kg for 30 days] produced significant (p]]>}</description>
		</item><item>
		<title>Solid-Dispersion-A-Recent-Update</title>
		<pubDate>03-Jun-2018</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/kps8VQ.pdf</link>
		<author>Midha-K-Rani-P-Arora-G-Nagpal-M-Kalra-S</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Solid dispersions have engrossed substantial attention as an effectual means of refining the dissolution rate and hence the bioavailability of a variety of hydrophobic drugs. In this review, it is intended to discuss the future prospects related to the area of solid dispersion manufacturing. Improving oral bioavailability of drugs those given as solid dosage forms remains a challenge for the formulation scientists due to solubility problems. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Therefore, increase in dissolution of poorly soluble drugs by solid dispersion technique presents a challenge to the formulation scientists. Solid dispersion techniques have attracted considerable interest of improving the dissolution rate of highly lipophilic drugs thereby improving their bioavailability by reducing drug particle size, improving wettability and forming amorphous particles. This review article discusses the various preparation techniques and characterization for solid dispersion and compiles some of the recent technology transfers in the form of patents. ]]>}</description>
		</item><item>
		<title>Preparation-and-In-Vitro-Evaluation-of-Self-Emulsifying-Drug-Delivery-System-for-Oral-Delivery-of-Glibenclamide</title>
		<pubDate>03-Jun-2018</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/JSh8ra.pdf</link>
		<author>Akiladevi-D-Nappinnai-M-Jerad-Suresh-A-Amudha-P</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[Objective: The present study was aimed to develop a novel o/w self-emulsifying drug delivery system (SEDDS)with novel synthetic oils, a variety of natural oils and surfactants/co surfactants to enhance the solubility and dissolution rate of poorly water soluble drug, glibenclamide thereby to improve its relative bioavailability. The novelty in this proposed research work is the simple process of production and easy to scale up with minimum infrastructure.Methods: The design of an optimal SEDDS is performed by preformulation solubility and ternary phase-diagram studies. The prepared self - emulsifying formulations were performed for in vitro evaluation studies of droplet size, polydispersity index, drug loading, zeta potential, optical clarity, turbidity, cloud point, viscosity determination, self-emulsification time assessment, in vitro drug release and in vitro diffusion studies.Results: The results showed that Peceol as oil, Labrasol as surfactant and Transcutol HP as cosurfactant prepared stable emulsions has a refractive index as same that of water clearly indicated that the microemulsions was highly transparent. The percentage drug release for optimal formulation of glibenclamide SEDDS after 30 minutes was found to be 99.7 % when compared to API (active pharmaceutical ingredient) and marketed tablet.Conclusion: This study demonstrated that in vitro drug release and in vitro diffusion study were dependent on critical parameters such as particle size and drug loading in SEDDS formulationsKeywords: Self -Emulsifying Drug Delivery, Glibenclamide, In vitro evaluation, Particle size, Drug loading]]>}</description>
		</item><item>
		<title>Meet-our-Editors</title>
		<pubDate>21-Mar-2018</pubDate>
<link>http://ijpp.edwiserinternational.com/admin/uploads/BOP9C3.pdf</link>
		<author>Editor</author>
		<comments>{http://www.edwiserinternational.com/contact-us.php}</comments>
		<category>Pharmaceutical Science,Medical Science</category>
		<description>{<![CDATA[We appreciate the contribution of all our Editors to International Journal of Pharmaceutics & Pharmacology. We are glad that with the kind support of our Editors we release the inaugural issue of the journal.You can find the short biographies of our Honorable Editorial Board Members.]]>}</description>
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